Storylines & Rules » tudies indicate that TLR10 is in the same locus

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Posted On : May-14-2009 | seen (874) times | Article Word Count : 383 |

Toll-like receptor 10 (TLR10) often known as CD290 (cluster of differentiation 290), is the most recently identified human homolog of the Drosophila TOLL protein. Human TLR10 is an orphan member of the Toll-like receptor family that recognizes pathogen-associated molecular pattern. Toll-like receptor 10 (TLR10) often known as CD290 (cluster of differentiation 290), is the most recently identified human homolog of the Drosophila TOLL protein. Human TLR10 is an orphan member of the Toll-like receptor family that recognizes pathogen-associated molecular pattern. Like other members of the TLR family Emanuele Giaccherini Italy Jersey , TLR10 contains a signal peptide, multiple leucine-rich repeats, a cysteine-rich domain, a transmembrane domain Eder Italy Jersey , and a cytoplasmic TOLL interleukin-1 receptor domain. The human TLR10 gene occupies 3,269 bases arranged in three exons on the short arm of chromosome 4 (4p14) and encodes an 811-amino acid protein, approximately 50% identical to TLR1 and to TLR6. TLR10 is most closely related to TLR1 and TLR6 with 48% and 46% overall amino acid identity, respectively. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene (1).

In vivo Davide Astori Italy Jersey , TLR10 mRNA expression is highest in immune system-related tissues including spleen, lymph node, thymus, tonsil. TLR10 mRNA is most highly expressed on B cells. In vitro [url=http://www.cheapitalyjerseys.com/daniele-padelli- atural ligand for TLR10 has not been identified yet. Genomic studies indicate that TLR10 is in the same locus that contains TLR1 and TLR6 and are also structurally similar to each other. It has been speculated that Ciro Immobile Italy Jersey , like TLR1 and TLR6, TL. Cheap Jerseys China Cheap Jerseys China Cheap Wholesale Jerseys Cheap Jerseys China Wholesale Cheap NFL Jerseys China Cheap NFL Jerseys Cheap Authentic NFL Jerseys Cheap NFL Football Jerseys Cheap NFL Football Jerseys Wholesale Jerseys